I'm very happy to say that my first first-author paper has been published in Bioinf. Advances! 1/2
academic.oup.com/bioinformati...
Exciting breakthrough technology from the lab, now live in
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
1\ Excited to finally share some of my PhD work: OpenSplice!
We measured how >590,000 mutations affect exon inclusion across 600 human exons, creating a resource to study splicing regulation, benchmark variant effect predictors, and support variant interpretation.
I am extremely honored and grateful to see our work featured on PreLights @prelights.bsky.social. If you want a quick dive into how acute loss of PRC2 impacts TLS formation, check out this excellent breakdown by María @mariamafau.bsky.social. I had a great time discussing the work with her.🔬👇
I'm very excited to announce that my PhD work is out on biorxiv!
pyTrance is a computational method to predict and quantify subcellular RNA co-localization from spatial transcriptomics data.
www.biorxiv.org/content/10.6...
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Video
Introducing openRxiv Labs! 🔬 Growing from the strong foundation of bioRxiv & medRxiv, Labs is an experimental space for working with collaborators to push the boundaries of open scientific communication.
👉 Check it out and learn more: openrxiv.org/openrxiv-lab...
#OpenScience #Preprints #Scicomm
1/n What fraction of the human genome is essential for cells?
Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads.
@sudpinglay.bsky.social @jshendure.bsky.social
www.biorxiv.org/content/10.6...
