Very glad to have our latest study, led by the former stellar PhD student @pharrissnell.bsky.social and postdoc Parisa Naeli, out in @cp-cellreports.bsky.social. Translation-dependent regulation of stability of non-optimal mRNAs by 2 vertebrate-specific RBPs, ZC3H7A/B.
www.cell.com/cell-reports...
Harris Snell et al. report that ZC3H7A and ZC3H7B, two chordate-specific RNA-binding
proteins, directly bind and coordinate the decay and translational regulation of A/U3-rich
non-optimal mRNAs. By re...
eIF5B-Driven Translational Control Impacts Oral Squamous Cell Carcinoma Pathophysiology.
From the talented PhD student Pavan Narasimha in Nehal Takhor lab. Great to see this work out in preprint and looking forward to more cool stuff from Pavan's recent works!
www.biorxiv.org/content/10.6...
This is brilliant!
Mehdi Jafarnejad
⭐NAR Breakthrough! ⭐
#RNAtherapeutics show strong promise for #CNSdisorders 🧠. #Preclinical studies reveal that very high doses of #oligonucleotides can cause brief, reversible neuronal activation driven by metal ion interactions 🧪.
Read the full article here: doi.org/10.1093/nar/...
RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions: Molecular Cell www.cell.com/molecular-ce...
There ain’t much that eIF3 doesn’t do! Very nice (and rather comprehensive) review on all things eIF3.
link.springer.com/article/10.1...
Answer to a key and longstanding question;
How does the integrated stress response terminate?
| Science www.science.org/doi/10.1126/...
Join us;
We have an opening for a BBSRC-funded 3-year postdoc position to investigate the mechanisms of mRNA-specific translational regulation of the innate immune system.
#Postdoc #RNA #RBP #MolecularBiology #Virology #RNASky #AcademicJobs
hrwebapp.qub.ac.uk/tlive_webrec...
🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...
RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP
www.biorxiv.org
Looking for a truly unique PhD programme on RNA drugs and therapeutics? We have just opened the call for the second cohort of RNAmed-Future leaders in RNA-based medicine. More details under www.rnamed.de Please spread the word.
Mehdi Jafarnejad
Mehdi Jafarnejad
Kretov et al. introduce RBPscan, an RNA-editing-based platform that measures how RNA-binding
proteins engage their targets in living cells. This approach quantifies the binding
strength of protein-RNA...
The eukaryotic translation initiation factor 3 (eIF3) is the largest and most complex initiation factor in eukaryotes, functioning as a central hub that integrates signals from cellular stress, metabo...
link.springer.com
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...
LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...
Max Fels @mfels.bsky.social from our lab discovers giant DNA viruses that infect amoeba encode eIF4E and the entire suite of 4F complex proteins to control mRNA translation, including beautiful crystal structures of viral 4E bound to modified mRNA 5' caps:
www.cell.com/cell/fulltex...
