A Perspective provides minimum community standards and best-practice guidelines for hydroxyl radical protein footprinting-mass spectrometry.
www.nature.com/articles/s41...
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This Perspective provides minimum community standards and best-practice guidelines for hydroxyl radical protein footprinting–mass spectrometry, including experimental design, sample preparation and ox...
TADShop: a study benchmarking 43 computational methods for identifying topologically associating domains. @ciriellolab.bsky.social
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Read the associated Research Briefing here:
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A Perspective discusses challenges in macromolecular ensemble prediction and the methodological advances that are needed. @stephanieaw.bsky.social
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A Perspective discusses the use of external validation using independent datasets for improving human neuroimaging studies. @dscheinost.bsky.social @matt-rosenblatt.bsky.social
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Chromatix: a standardized framework for developing, sharing and reusing wave-optics simulations.
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Brightness demixing: a method for simultaneously detecting different fluorophores in single-molecule localization microscopy based on brightness. @slfort.bsky.social @laurent-le.bsky.social @ismolab.bsky.social @instlangevin.bsky.social
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Neuropixels Opto probes combine high-density recording sites with optical waveguide-based light emission sites to simultaneously record neuronal activity and optogenetic stimulation.
@carandinilab.net @uclbrainscience.bsky.social @alleninstitute.org
www.nature.com/articles/s41...
SAGE-net: a scalable, efficient sequence-to-function modeling framework for personal genome analysis.
www.nature.com/articles/s41...
And read the associated Research Briefing here:
www.nature.com/articles/s41...
This Perspective discusses current challenges in macromolecular ensemble prediction and the infrastructure and methodological advances needed to overcome these barriers.
This study benchmarks 43 computational methods for identifying topologically associating domains (TADs), presents a tool based on a consensus strategy that leads to improved performance, and releases ...
High-density electrophysiology devices allow neuroscientists to observe spikes from large populations of neurons, and optogenetics allows them to drive or suppress those spikes. We show that a single ...
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This Perspective promotes the use of external validation using independent datasets for human neuroimaging studies.
Based on JAX, Chromatix provides a standardized framework for developing, sharing and reusing wave-optics simulations. The capabilities are demonstrated in a number of computational microscopy applica...
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Brightness demixing is a method for simultaneously detecting different fluorophores in single-molecule localization microscopy based on their brightness rather than their spectral properties. As this ...
Neuropixels Opto probes combine high-density recording sites with optical waveguide-based light emission sites for simultaneous recording of neuronal activity and optogenetic stimulation with blue and...
Modeling the effect of DNA sequence variation on phenotypes such as gene expression faces unique challenges when deciphering inter-individual variation. This study presents a scalable and efficient se...
We built an open-source library of wave optics models — Chromatix — that enables optics simulations to be scaled efficiently on modern computing hardware. Chromatix solves computational optics problem...
