A scientific journal publishing cutting-edge methods, tools, analyses, resources, reviews, news and commentary, supporting life sciences research. Posts by the editors.
Nature Methods
Loading...
A Perspective provides minimum community standards and best-practice guidelines for hydroxyl radical protein footprinting-mass spectrometry.
www.nature.com/articles/s41...
Our June issue is live! 🎉
www.nature.com/nmeth/volume...
On the cover, an absolutely gorgeous image of neurites and mitochondria in a brain organoid, captured using the MOSAIC microscope.
Paper here: www.nature.com/articles/s41...
Neuropixels Opto probes combine high-density recording sites with optical waveguide-based light emission sites to simultaneously record neuronal activity and optogenetic stimulation.
@carandinilab.net @uclbrainscience.bsky.social @alleninstitute.org
www.nature.com/articles/s41...
A Perspective discusses challenges in macromolecular ensemble prediction and the methodological advances that are needed. @stephanieaw.bsky.social
www.nature.com/articles/s41...
Brightness demixing: a method for simultaneously detecting different fluorophores in single-molecule localization microscopy based on brightness. @slfort.bsky.social @laurent-le.bsky.social @ismolab.bsky.social @instlangevin.bsky.social
www.nature.com/articles/s41...
And read the associated Research Briefing here:
www.nature.com/articles/s41...
A Perspective discusses the use of external validation using independent datasets for improving human neuroimaging studies. @dscheinost.bsky.social @matt-rosenblatt.bsky.social
www.nature.com/articles/s41...
SAGE-net: a scalable, efficient sequence-to-function modeling framework for personal genome analysis.
www.nature.com/articles/s41...
Chromatix: a standardized framework for developing, sharing and reusing wave-optics simulations.
www.nature.com/articles/s41...
Read the associated Research Briefing here:
www.nature.com/articles/s41...
This Perspective provides minimum community standards and best-practice guidelines for hydroxyl radical protein footprinting–mass spectrometry, including experimental design, sample preparation and ox...
Neuropixels Opto probes combine high-density recording sites with optical waveguide-based light emission sites for simultaneous recording of neuronal activity and optogenetic stimulation with blue and...
www.nature.com
This Perspective discusses current challenges in macromolecular ensemble prediction and the infrastructure and methodological advances needed to overcome these barriers.
Brightness demixing is a method for simultaneously detecting different fluorophores in single-molecule localization microscopy based on their brightness rather than their spectral properties. As this ...
www.nature.com
We built an open-source library of wave optics models — Chromatix — that enables optics simulations to be scaled efficiently on modern computing hardware. Chromatix solves computational optics problem...
This Perspective promotes the use of external validation using independent datasets for human neuroimaging studies.
www.nature.com
Modeling the effect of DNA sequence variation on phenotypes such as gene expression faces unique challenges when deciphering inter-individual variation. This study presents a scalable and efficient se...
Based on JAX, Chromatix provides a standardized framework for developing, sharing and reusing wave-optics simulations. The capabilities are demonstrated in a number of computational microscopy applica...
High-density electrophysiology devices allow neuroscientists to observe spikes from large populations of neurons, and optogenetics allows them to drive or suppress those spikes. We show that a single ...
