🆕 New paper out with Jean-Luc Imler and Rune Hartmann in EMBO journal.
We dissect mechanisms of antiviral immunity and how STING is activated by FADD and DREDD during viral infection in Drosophila melanogaster. link.springer.com/article/10.1...
STING is an evolutionarily conserved key regulator of innate immunity. In the model organism Drosophila melanogaster, STING activates the NF-κB-like transcription factor Relish, initially characterize...
Integrated small and long RNA sequencing reveals piRNA mediated transposon repression during human oogenesis www.nature.com/articles/s41...
The roles of the piRNA pathway in human oocytes are poorly understood. Here, the authors profile small and long RNAs in single oocytes and show that short piRNAs broadly repress transposable elements,...
Germ cells have their own versions of core transcription factors and fertility depends on them.
We're hiring a PhD student to figure out how! 📢
Fly genetics + proteomics + genomics. Fully funded.
Aarhus University 🇩🇰
Deadline May 1 👇
Please share with anyone who might be interested!
Navin B. Ramakrishna
Which transcription factors control transposable element expression during zygotic genome activation?
Gain-of-function screen by @metorrespadilla.bsky.social and coworkers identifies TBP as direct regulator of mouse endogenous retrovirus-like elements
link.springer.com/article/10.1...
Pierre Bourguet (@p-bourguet.bsky.social) has been awarded a Marie Skłodowska-Curie Postdoctoral Fellowship for the RegulatoryTEmbryo project at IBMP! His project explores how transposable elements shape plant embryogenesis and rewire developmental gene networks.
#MSCA
Drosophila border cells are beautiful to watch… but far from easy to image. Kudos to the brave and skilled @vitoryang.bsky.social, who took on the challenge of establishing border cell migration imaging in the lab! His movies are astonishing, and now our first-ever study on #cell #migration is out!
🚨📢📄 Article in press in Genome Biology doi.org/10.1186/s130...
We introduce panREPET, a reference-free pipeline to detect shared transposable element (TE) insertions across pangenomes and retrace their evolutionary dynamics #TEsky 🧵👇
www.science.org/doi/10.1126/...
Such sad news. He was a major contributor to small RNA biology — an inspiring scientist and such a kind collaborator. I have no words 🥲 www.cruk.cam.ac.uk/news/in-memo...
Love Drosophila genetics — this journal club was a great way to share that enthusiasm and pay tribute to the pioneers of transposons regulation 🪰 How classical genetics uncovered key determinants of TE silencing #transposon @igred.fr
@igred.fr
👇👇
phd.nat.au.dk
The activation of the embryonic genome is a crucial step in development. In addition to thousands of genes, many transposable elements (TEs) are robustly transcribed during early mammalian development...
Background The role of transposable elements (TEs) in host adaptation has gained interest in recent years. Individuals of the same species undergo independent TE insertions, providing genetic variabil...
Greg was already a world-renowned scientist when appointed Director, and for the community, he was a visionary leader, a cherished mentor, and a singular force of nature whose influence shaped the research landscape.
IBMP | Institut de biologie moléculaire des plantes
Emilie Brasset
Eurico Morais-de-Sá
Johann Confais
New online! How classical genetics uncovered key determinants of TE silencing
Collective #migration requires balancing force and flexibility. @vitoryang.bsky.social, @polarityi3s.bsky.social et al. identify RhoGAP15B as a local brake on RhoA-#myosin contractility in border cells, stabilizing front protrusions and coordinating group movement rupress.org/jcb/article/...
Video
Nature Reviews Genetics, Published online: 25 March 2026; doi:10.1038/s41576-026-00951-5In this Journal Club, Emilie Brasset highlights a 1995 publication by Prud’homme et al., who designed a clever genetic assay to identify a gene important for TE silencing, which provided a crucial foundation for later studies to unravel the underlying mechanisms.
