Our study suggests that LC lesions exacerbate pre-existing behavioral deficits and AD pathology, rather than accelerating their onset. Such nuance in understanding the contributions of LC dysfunction to dementia progression is necessary for developing effective therapeutics targeting this system.
New manuscript from undergrad Alexia and
@davidweinshenker.bsky.social on the molecular and behavioral effects of early locus coeruleus lesions in the TgF344-AD rat model
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...