This Visual-omics approach is kind of amazing: "We resolved each to sufficient
resolution (2.8 and 3.6 Å) to predict the amino acid composition directly from the 3D electrostatic potential map"
Excited to be presenting this work today at the 3DEM Gordon Research Seminar and later this week at the Gordon Research Conference. Looking forward to the discussions and feedback!
www.grc.org/three-dimens...
including state-of-the-art #CryoET #CryoEM #teamtomo
The 2026 Gordon Research Conference on Three Dimensional Electron Microscopy will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
CPR bacteria form a superphylum that may account for 15–50% of all bacterial diversity (!!), yet we know remarkably little about them. Recently, we showed that the dwarf CPR bacterium JR1 entangles its host with specialized filaments and kills using a lance-like structure. 🦠⚔️
STCmicrobeblog
Video
New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀
The Candidate Phyla Radiation (CPR) represents a bacterial superphylum estimated to include between 15–50% of all bacterial species, yet CPR bacteria remain challenging to culture and have been primar...
www.biorxiv.org
By using visual-omics, we managed to assign the molecular identity of these filaments directly from structure, without relying on sequence homology. It turned out to be a completely novel filament system, never before described in any bacteria.
