Does protein dimerization always help targeting and dwell time on DNA? Not for a population! Dwell time is especially sensitive to spacing between DNA targets. Nonspecific binding and facilitated (1D) diffusion also play a key role. Super proud of Mankun Sang’s work!
doi.org/10.1101/2025...
How much do dimer binding affinities change for proteins on the 2D membrane vs in solution? We go beyond rigid-body entropy estimates to show conformational variations can strongly select for 2D association. Very proud of Dr Adip Jhaveri and team's comprehensive work! doi.org/10.1063/5.02...
Driving membrane fission is not quite as hard as it seems (at least to me!). Very happy to contribute to this work from Wade Zeno’s lab!
📣 To celebrate Biophysics Week, the Membrane Structure and Function Subgroup (MSAF) of @biophysicalsoc.bsky.social will host a webinar on March 24 at 11am EDT. Our speakers are @mejohnson81.bsky.social, @ibudin.bsky.social, and Cecília Leal (not on 🦋). 🧪
👀 More info in the alt text! Please share! 🔄
For any of my friends at the #APS Global Physics Summit, come to the Macromolecular Assembly in Cells II session today at 3pm to hear from me about how clathrin self-assembly is tuned to sense cargo receptors!
Dimerization underpins all macromolecular assembly processes, both on and off the membrane. While the strength of dimerization, KD, is commonly quantified in so
New preprint from my lab! Clathrin doesn’t bind membranes directly, yet it can still drive membrane bending and fission by transmitting its mechanical properties through adaptor proteins.
Our collaborators:
@samuelfoley.com
@mejohnson81.bsky.social
BioRxiv link:
www.biorxiv.org/content/10.6...
Can sensing of membrane receptors be switched on at tunable threshold densities, without active processing? Proud to share this preprint led by the awesome Dr Foley, please check it out!
