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After making a bunch of degraders (most not shown here), we arrive at NK250 and NK266 ("Kurt Cubane"), two highly potent USP7 degraders in HiBiT and immune-based assays. NK250, is a faster degrader which we could correlate to its ability to form a stable ternary complex between USP7 and VHL.
11mo
Lastly, a huge thank you to my supervisor Dr. @maltegersch.bsky.social for his guidance and support, as well as the entire Gersch team. I am very glad to share this story, but even more excited for whats to come in the (near) future, so stay tuned, we are just getting started! #TPD #PROTAC #DUB
11mo
This work would not have been possible without my amazing co-first authors Dr. Sebastian Urban and Dr. Med. Johanna Seier and everyone in this highly interdisciplinary team from the @crc1430.bsky.social and beyond.
#Deubiquitinases (DUBs), key regulators of ubiquitin signaling, have been increasingly recognized for functions beyond rescuing substrate proteins from proteasomal degradation. Due to a lack of selective chemical tools within the DUB space, finding these functions has proven to be very challenging.
Niko Klink
11mo