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Big thanks also to Dr. Bikash Adhikari and Prof. Elmar Wolf from @wolflab23.bsky.social, as well as Dr. @martinschwalm.bsky.social for bringing their expertise to this project, @imprs-lm.bsky.social from the MPI Dortmund for the excellent support and everyone else who contributed to the prokect!
Taking these now to our Model Systems (PDAC and melanoma), not only shows highly selective degradation of USP7 by our PROTACs (criteria for matched pair fulfilled!), but also striking differences between inhibitor and degrader treated cells. These differences also occur in many phenotypic assays!