Did you know that Pierre Chambon's laboratory was the first to use the term "nucleosome" in 1975 ?
www.cell.com/cell/fulltex...
1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬
Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles
By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪
🧵👇
Although cohesin-sensitive, long-range enhancer activation is equivalent in nature to proximal activation. Cooperativity can arise from different levels of activation inputs operating on a non-linear response function. @eliasfriman.bsky.social @uoe-igc.bsky.social
www.biorxiv.org/content/10.6...
Going from the discovery of epigenetic silencing of CTCF insulators www.nature.com/articles/s41... to aberrant E-P looping www.cell.com/molecular-ce... to a successful clinical trial www.nature.com/articles/s41... all from Brad Bernstein's lab
Alexis Verger 🧬🧫🧪
Video
Gastrointestinal stromal tumours can be initiated by gain-of-function mutations of the KIT or PDGFRA oncogenes but also by loss of the metabolic complex succinate dehydrogenase (SDH), which leads to D...www.nature.com
