Going from the discovery of epigenetic silencing of CTCF insulators www.nature.com/articles/s41... to aberrant E-P looping www.cell.com/molecular-ce... to a successful clinical trial www.nature.com/articles/s41... all from Brad Bernstein's lab
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Gastrointestinal stromal tumours can be initiated by gain-of-function mutations of the KIT or PDGFRA oncogenes but also by loss of the metabolic complex succinate dehydrogenase (SDH), which leads to D...
