Secreting bacteria undergo drastic changes.
We found that in Yersinia, T3SS activation triggers rapid, large-scale reorganisation of chromosomal and plasmid DNA. This links secretion to growth inhibition-revealing a new connection between virulence and bacterial cell biology.
doi.org/10.1016/j.ce...
T3SS activity comes at a cost—bacteria that use the system pay with reduced growth. We found how Yersinia balance costs and benefits: at higher densities, they actively suppress T3SS activity and adhesion, switching from colonization to replication and dissemination.
doi.org/10.1371/jour...
@kit.edu
Special thanks 🙏 go to first author @ljmihajlovic.bsky.social , as well as Lara Hofacker, Florian Lindner, Priyanikha Jayakumar, and collaborator @diepold-lab.bsky.social !
Our first accepted manuscript at my new lab (@kitkarlsruhe) is out in Communications Biology! 🎉
We show how Pseudomonas aeruginosa coordinates its virulence systems, T3SS, H1-T6SS, flagellum, at single-cell resolution.
🔗 www.nature.com/articles/s42...
@t3sss.bsky.social @NaturePortfolio.bsky.social
This is the first of three manuscripts we’ve recently had accepted — more to come soon! 🚀
#Microbiology #InfectionBiology #SingleCell
Using live-cell microscopy, we uncovered distinct bacterial subpopulations that primarily use certain combinations of these nanomachines:
• some prioritize motility & T3SS
• others shift to T6SS for antagonism
All tuned by the usual suspect: cyclic di-GMP.
🛠️Toolbox 🛠️ out to modulate gene expression & protein secretion in a predatory bacterium.
📑Preprint from my group below.
Many thanks to L. Mihajlovic @ljmihajlovic.bsky.social, L. Hofacker, F. Lindner, P. Jayakumar & A. Diepold @diepold-lab.bsky.social! #MicroSky #SyntheticBiology #PredatoryBacteria