New preprint
We identify a conserved intramolecular interaction in KANK proteins.
We show that the KANK KN domain contains separable functional modules: the LD motif mediates talin binding, while residues 60-68 mediate interaction with the KANK ankyrin repeat domain
doi.org/10.64898/202...
Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...
Almost 40 years later, has anyone identified what "buttonin", the 75-kD protein that decorates microtubule like buttons, is? dx.doi.org/10.1083/jcb.104.6.1553
Okay want to talk blebs, migration, life and more!!! I will be at poster session (sunday) at 2 PM at poster board- 247 at @ascbiology.bsky.social #Cellbio2025
Force-dep. FHL2 localization to stress fibers induces actomyosin contractility & atherosclerosis-like phenotypes in endothelial cells–new paradigm for mechanochemical feedback
Shailaja Seetharaman @sseethar.bsky.social Margaret Gardel @squishycell.bsky.social et al
link.springer.com/article/10.1...
Kate Miroshnikova
Ben Goult
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
Ankita Jha
new role for FAT1 beyond being a protocadherin: a mechanotransduction mediator.
Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis
pubs.aip.org/aip/apb/arti...
The EMBO Journal
We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
Christophe 🔬 Leterrier
Manuel Thery
Manuel Thery
Jon Humphries
Maria Bernabeu
Mechanical forces are fundamental to the formation of normal biological tissues and the maintenance of physiological health. These forces are transmitted from t
This week #JournalClub @cellpress.bsky.social #membrane #pressure #Hippo #density www.sciencedirect.com/science/arti...
LabSoap
Endothelial tissues are essential mechanosensors in the vasculature, and defects in their response to mechanical cues such as blood flow can lead to endothelial dysfunction and cardiovascular diseases...
Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...
