Self-amplifying RNA improves heart function after myocardial infarction in mice and pigs @science.org @columbiauniversity.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times.
www.thermofisher.com/us/en/home/l...
www.thermofisher.com
Nature research paper: Single-cell and isoform-specific translational profiling of the mouse brain
go.nature.com/4aYPQu7
Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hippocampal neuronal and non-neuronal cell types, highlighting functional differences between CA1 and CA3.
go.nature.com
Nature
My first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances!
He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding.
See more details in EMBL post below!
With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268
Congratulation Ahmad! Beautiful!
So, as translation control is getting popular, please note the newly unified nomenclatures:
Translons: a single term for translated regions
www.nature.com/articles/s41...
Peptideins: translated ORFs lacking sufficient evidence for protein-coding gene status
www.nature.com/articles/s41...
