A lab of #RNA lovers, obsessed with #tRNA, #mRNA, #ribosomes, and #translational control in health and disease.
IgnatovaLab
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My first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances!
He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding.
See more details in EMBL post below!
Self-amplifying RNA improves heart function after myocardial infarction in mice and pigs @science.org @columbiauniversity.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times.
www.thermofisher.com/us/en/home/l...
So, as translation control is getting popular, please note the newly unified nomenclatures:
Translons: a single term for translated regions
www.nature.com/articles/s41...
Peptideins: translated ORFs lacking sufficient evidence for protein-coding gene status
www.nature.com/articles/s41...
Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...
We are looking for RNA enthusiasts to join us at the @uniregensburg.bsky.social as a junior group leader! Our university offer excellent infrastructure and collaboration opportunities for ground breaking RNA research. Please RT @jrrnascientists.bsky.social @rnasociety.bsky.social
With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268
Incredibly proud of our small but mighty team at Interdict Bio as we bring the interdictor modality closer to the clinic! Check out our first publication that lays the foundation for context-dependent translation modulators as a therapeutic approach for cancer!
www.nature.com/articles/s41...
Nature research paper: Single-cell and isoform-specific translational profiling of the mouse brain
go.nature.com/4aYPQu7
In @science.org this week, thermospermine affects ribosome methylation, which in turn regulates translation of xylem development proteins www.science.org/doi/10.1126/...
#plantscience
Video
Nature Methods - Translon: a single term for translated regions
Robust protein synthesis by the ribosome is required for rapid cancer growth. Here authors present interdictors, small molecule inhibitors of protein synthesis with context-dependent activity that inh...
www.nature.com
Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hippocampal neuronal and non-neuronal cell types, highlighting functional differences between CA1 and CA3.
Polyamines are often associated with ribosomes and are thought to stabilize their integrity. In Arabidopsis, the polyamine thermospermine (tSpm) affects xylem cell fate. tSpm induces translation of SU...
(1/2) EMBL researchers led by @olivierduss.bsky.social have developed a microscopy technique that enables them to observe individual RNA molecules being produced and folding into different shapes.
Learn more: www.science.org/doi/10.1126/...
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
