☕ @nicolettapetridou.bsky.social & co report a feedback loop between Nodal signaling and tissue phase transitions in zebrafish #embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which limits its diffusion and speeds up Lefty expression.
go.nature.com/4vgBYmo
go.nature.com
Autorino et al. report a feedback loop between Nodal signalling and tissue phase transitions in zebrafish embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which l...
In a collaboration between the Crick and @embl.org, researchers used a mix of experimental work in zebrafish and theoretical modelling to discover a feedback loop between an embryo’s changing material properties, such as its rigidity, and the signalling molecules that guide patterning.
How rigid a tissue is coordinates a crucial period of cell patterning, ensuring that embryos develop the right shape and organise their cell layers correctly at the same time.
EMBL graduated its biggest class ever at the end of April, celebrating with 60 fellows who submitted or defended their theses over the past 12 months.
Representing 22 different countries, EMBL graduates continued to show a diversity in science as well as background. Congratulations graduates!
💫 Our paper is now published at @natcellbio.nature.com! So excited about this work done during my PhD at @embl.org in the group of @nicolettapetridou.bsky.social along with our great collaborators! 🐟🎉
Very happy to announce that I will be joining the Faculty of Biology & @cibss.bsky.social at @uni-freiburg.de as an Emmy-Noether funded group leader.
We will tackle the molecular and genetic basis of developmental timing and size control using diverse Oryzias species. We are hiring at all levels !
⚡ Our paper is now out in @natphys.nature.com !
This version now includes a detailed molecular characterisation of the optogenetic perturbations, new insights on the relevance of tricellular junctions for tissue morphology, and beautiful light-sheet timelapses. 🔬
www.nature.com/articles/s41...
Camilla Autorino
Camilla Autorino
Camilla Autorino
Camilla Autorino
Camilla Autorino
Xavier Trepat
www.nature.com
Laura Rustarazo-Calvo
Tissue phase transitions are key to morphogenesis. Now adhesion-driven rigidification is identified as key to epithelial organization but only if uncoupled from density-driven jamming.
🎉 Excited to share our new work: “Adhesion-driven tissue rigidification triggers epithelial cell polarity”, now on @biorxivpreprint.bsky.social !
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
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Video
How can structures at the vertex of 3 cells have effects at the tissue level?
Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...
Laura Rustarazo-Calvo
Video
🍰Read also the Research Briefing:
👉https://rdcu.be/flTlO
bit.ly/4wWf0CF
Nature Cell Biology
During embryogenesis, morphogen signalling is known to pattern tissues as they remodel. Using genetic and optogenetic perturbations, together with theoretical frameworks of phase transitions and bioch...
Join us for the next VGZT, featuring complementary approaches to understanding dynamic tissue organization!
🗓️ Thursday, January 22nd
⏰ 9:30 PST / 12:30 EST / 17:30 GMT / 18:30 CET
Our speakers are
👉 Chen Yuan Kam (@chenyuankam.bsky.social)
👉 Camilla Autorino (@cami-autorino.bsky.social)
Glad to see this out in its final form!
www.nature.com/articles/s41...
What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏
epithelial mechanics fan club
Autorino et al. report a feedback loop between Nodal signalling and tissue phase transitions in zebrafish embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which l...
Here our latest work on how morphogens trigger tissue phase transitions to tune their own length-scales and time-scales - An exciting collaboration with @zhvas.bsky.social @dianakhorom.bsky.social Bernat Corominas-Murtra and heroic experiments by the incredible @cami-autorino.bsky.social @embl.org
Nicoletta Petridou
🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨
“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶
🔗 www.biorxiv.org/content/10.1...
#devbio #biophysics
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