Excited to share a new preprint - We identify a characterize a functional interaction between SLC15A4 and LAMTOR1, providing new insights how this transporter regulates mTOR activation & inflammatory responses downstream of endolysosomal TLRs. Congrats to the team! www.biorxiv.org/content/10.6...
How do PTMs affect the binding of small molecule drugs to their target proteins?
Great to see @dereklowe.bsky.social highlight the recent paper by the group of @chrisgparker.bsky.social in "In the Pipeline".
Blog post: www.science.org/content/blog...
Paper: www.nature.com/articles/s41...
(1/4)
Findings from Prof. Chris Parker's lab show that post-translational modifications (PTMs) can determine whether proteins bind drug-like molecules. Published in Nature Chemical Biology, the study identified 400+ proteins whose druggability depends on modification state. More: https://ow.ly/3OQj50YVecw
Happy to share the final version of this work is now out in @natchembio.nature.com. Lots of additional exciting data! Congrats to all the authors!
New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇
www.biorxiv.org/content/10.6...
Congrats Ben!
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
Endolysosomal Toll-like receptors (TLRs) 7-9 are critical mediators of antimicrobial immunity, but their dysregulation drives pathogenic inflammation in autoimmune diseases such as systemic lupus eryt...
A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor...
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
Scripps Research
Chris Parker
Wiseman Lab
Chris Parker
Scripps Research
Stephan Hacker
A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor...
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...
Congratulations to #NASmember Benjamin F. Cravatt of @scripps.edu, winner of the 2026 NAS Award in Chemical Sciences for providing foundational insights into enzyme function and dysregulation in disease! Learn more about his discoveries: www.nasonline.org/award/nas-aw... #NASaward #chemistry
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
National Academy of Sciences
Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...
