How do PTMs affect the binding of small molecule drugs to their target proteins?
Great to see @dereklowe.bsky.social highlight the recent paper by the group of @chrisgparker.bsky.social in "In the Pipeline".
Blog post: www.science.org/content/blog...
Paper: www.nature.com/articles/s41...
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A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor...
