Assistant Professor at Leiden University. Covalent inhibitors and chemoproteomics for antibiotics. Views my own. he/him/his. https://orcid.org/0000-0001-5420-4824
Stephan Hacker
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There is still a chance to apply to present the #ChemBio research of your #PhD or #postdoc at the 6th Virtual @chembiotalks.bsky.social on September 29th (Deadline: June 15th).
You can apply by submitting an abstract to our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
One week left to apply to present your #ChemBio research to a broad international audience at the 6th Virtual ChemBioTalks on September 29th! 𝐃𝐞𝐚𝐝𝐥𝐢𝐧𝐞: 𝐉𝐮𝐧𝐞 15𝐭𝐡.
If you are interested, apply by participating in our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
We are looking forward to the LED3 Lecture by Madelon Maurice on June 25th. She will talk about "SureTACs: A novel modality for targeted degradation of cell surface proteins".
If you are interested, make sure to come by!
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #DrugDiscovery
The #YoungScientistAward of the @gdch.de Division of Biochemistry is open for applications and nominations!
If you are or have supervised a PhD with an outstanding publication or PhD thesis, make sure to check out the award!
en.gdch.de/network-s...
#ChemSky #ChemBio #Biochemistry
He then talked about the use of AI to predict antibacterially active compounds that can be made from commercial fragments in straightforward chemical reactions and how they applied this strategy to the discovery of synthecin, active against S. aureus. (3/4)
link.springer.com/article/10.1...
Initially, he introduced The ESKAPE Model that they are hosting to democratize the use of AI to predict antibacterial activity against the ESKAPE pathogens. (2/4)
eskape.mcmaster.ca
Very excited that we will be hosting Madelon Maurice (@mauricelab.bsky.social) for a @led3hub.bsky.social Lecture on June 25th. I am looking forward to learning about their work on new degrader modalities and the Wnt pathway.
If you are interested, come by.
www.universiteitleiden.nl/en/science/l...
Finally, he discussed the application of AI to predict the mechanism-of-action of an antibacterial compound on the example of enterololin, which they identified as an antibiotic against pathogenic Escherichia coli. (4/4)
www.nature.com/articles/s41...
Jon Stokes gave an inspiring and highly interactive @led3hub.bsky.social Lecture. He talked about the power and the limitations of AI for antibiotic drug discovery. (1/4)
www.thestokeslab.com
#ChemSky #ChemBio #DrugDiscovery #Antibiotics #AI #MachineLearning
We are very happy that Jon Stokes from McMaster University visited us today for a LED3 Lecture. He gave "An honest discussion about AI for antibiotic discovery".
www.nature.com/articles/s43...
#ChemSky #ChemBio #AI #MachineLearning #Antibiotics
CC: @leidenscience.bsky.social
The rise of antibiotic-resistant pathogens such as Staphylococcus aureus has created an urgent need for new antibiotics. Generative artificial intelligence (AI) has shown promise in drug discovery, bu...
Enterololin is a narrow-spectrum antibiotic that selectively kills Enterobacteriaceae in vitro and in a mouse model of adherent-invasive Escherichia coli gut infection. AI-guided mechanism-of-action s...
