'If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research.'
link.springer.com/article/10.1...
WTAP tetramer ensures m6A writer assembly and faithful mitosis
link.springer.com/article/10.1...
Matthias Soller
Matthias Soller
Kurianlab
After having seen mediocre scholars from so-called top universities and top scholars from so-called mediocre universities, I can say that this is the way: University of Zurich withdraws from international university ranking. www.swissinfo.ch/eng/educatio...
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
EMBO Reports - When experimental controls go wrong, it does not necessarily mean your experiment is flawed. It might well be the first sign of something unexpected.
Very glad to have our latest study, led by the former stellar PhD student @pharrissnell.bsky.social and postdoc Parisa Naeli, out in @cp-cellreports.bsky.social. Translation-dependent regulation of stability of non-optimal mRNAs by 2 vertebrate-specific RBPs, ZC3H7A/B.
www.cell.com/cell-reports...
NSUN2 is an enzyme that adds a small chemical mark to RNA molecules and uniquely selects its targets based on specific sequence patterns and structural features.
www.nature.com
Thiago Carvalho
If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202....
They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.
David McQuarrie
The University of Zurich is withdrawing from the university ranking published by the Times Higher Education magazine stating it creates "false incentives."
The m6A methyltransferase complex (“writer”) regulates mRNA stability and translation, but how its assembly is orchestrated remains incompletely understood. Wilms’ tumor 1-associating protein (WTAP) i...
link.springer.com
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
So, as translation control is getting popular, please note the newly unified nomenclatures:
Translons: a single term for translated regions
www.nature.com/articles/s41...
Peptideins: translated ORFs lacking sufficient evidence for protein-coding gene status
www.nature.com/articles/s41...
Harris Snell et al. report that ZC3H7A and ZC3H7B, two chordate-specific RNA-binding
proteins, directly bind and coordinate the decay and translational regulation of A/U3-rich
non-optimal mRNAs. By re...
Thermo Fisher has responded to research integrity activists who spotted apparent manipulation in its antibody catalog:
"In ... preparing antibody images for publication on our website, some images may have been adjusted to clarify for presentation purposes."
More:
cen.acs.org/research-int...
Cas12a2 enables RNA-triggered, sequence-specific killing of eukaryotic cells via widespread DNA shredding, allowing selective elimination of cells on the basis of gene expression, including virus-infe...
