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We thank B. List and L. Alama for highlighting our collaboration pubs.acs.org/doi/10.1021/... in Synfacts! #ChemSky #photocatalysis Synthesis of α-Amino Acids via ConPET-Driven Amide Activation doi.org/10.1055/a-27...
4mo
KoenigChemistry
We broadened the scope of 4-isoxazolines and oxa-aza-BCHeps in a highly regioselective fashion by photocontrol over strain and topology. A template for designing next-generation therapeutics and agrochemicals! Congrats to the team! doi.org/10.26434/che...
1mo
Happy to see that our publication pubs.rsc.org/en/content/a... is part of the Key Highlights in @greenchemistry.rsc.org
3mo
A mild strategy compatible with various solvents, air, and moisture @angewandtechemie.bsky.social Congratulations to all involved! Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor–Donor Diazo Compounds doi.org/10.1002/anie...
Our combination of metal- and photocatalysis enables the selective synthesis of aniline under mild conditions and allows easy scaling with flow systems. Nice team work! #ChemSky #photocatalysis doi.org/10.1002/chem...
Our perspective charts the potential of water as a programmable reaction medium using compatible catalysts, EDA complexes, engineered micelles and microdroplets. Aqueous-phase organic photochemistry: Distinct modes and interfaces #ChemSky #photochemistry #watersoluble doi.org/10.1016/j.ch...
Electrochemistry enables sustainable access to phosphorylated amine libraries from natural feedstocks, yielding bioisosteric analogues of amino acid derivatives. Congrats to the team! #ChemSky #electrochemistry doi.org/10.1039/D6QO...
'On Water' hydrogen bonding stabilizes the photo-excited state of quinones: application of Franck-Condon principle in organic synthesis. Congrats to all! #ChemSky #photocatalysis doi.org/10.1038/s414... “On-water” photosensitization enables redox neutral acylation and alkylation of quinones
From donor/core CV to catalyst design: a new method to develop inexpensive and tunable organic RL/NIR photocatalysts. Dual Ni/photoredox C–heteroatom coupling with a new cyanoarene photocatalyst under 620 nm LEDs! @angewandtechemie.bsky.social #Chemsky #photocatalysis doi.org/10.1002/anie...
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We used industrially preferred solvents, base, and low catalyst loadings to offer a significant advancement in the practicality and scalability of industrial processes. Another collaboration with Bayer! pubs.acs.org/doi/10.1021/...
4mo
KoenigChemistry
5mo
KoenigChemistry
Three-dimensional, conformationally rigid molecular architectures are increasingly valued in chemical biology, and drug discovery, yet their syntheses often rely on step-intensive or metal-mediated methods. Herein, we report a metal-free, redox-neutral ...
doi.org
Divergent [3+2] Photocycloadditions of Nitrones to Isoxazolines and Oxa-Aza-Bicycloheptanes: Controlling Entry and Exit from Flatland | ChemRxiv
Geminal difunctionalization of readily available building blocks provides rapid access to molecular complexity. This work introduces a strategy for installing two distinct functional groups on a carb...
doi.org
Photochemical activation of N-phenylphenothiazine (PPT) enables a selective direct benzene amination with hydroxylamine in the presence of various vanadium catalysts under mild reaction conditions. S...
Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor–Donor Diazo Compounds
Photocatalytic Vanadium‐Mediated Amination of Benzene With Hydroxylamine
doi.org
Given the widespread use of organophosphorus scaffolds in several disciplines, the formation of C(sp3)–P bonds is of fundamental importance. Direct access to α-phosphorylated amines still remains chal...
doi.org
Water-oil interfaces exhibit high cohesive energy density and form a supramolecular hydrogen-bonding network, which supports organic reactions in various ways. Here, the authors introduce the redox-ne...
doi.org
KoenigChemistry
A generalized electrochemical dehydrogenation approach en route to α-phosphorylated amines
“On-water” photosensitization enables redox neutral acylation and alkylation of quinones - Nature Communications
KoenigChemistry
From redox numbers to red light: Donor oxidation and core reduction potentials predict E0-0 in cyanoarene dyes, guiding selection of an efficient red-light catalyst, 4MeODPATPN (PC13). Under 620 nm l...
doi.org
Predictive, Data‐Driven Design of Red‐Light Photoredox Catalysts for C─Heteroatom Bond Formation
KoenigChemistry
KoenigChemistry
We present a novel copper-catalyzed method for aniline cross-couplings promoted by a 6-hydroxy picolinhydrazide ligand. The method achieves room-temperature reactivity with aryl bromides, enabled by a methanol/ethanol solvent mixture and a mild, functional group-compatible base, with catalyst loadings as low as 0.5 mol %. The use of industrially preferred solvents and base, as well as the high catalytic activity, offers a significant advancement in the practicality and scalability of industrial processes. Furthermore, the approach extends to the cross-coupling of aryl chlorides under elevated temperatures and demonstrates compatibility with additional nucleophile classes.
pubs.acs.org
Room-Temperature Copper Cross-Coupling Reactions of Anilines with Aryl Bromides
KoenigChemistry
KoenigChemistry
KoenigChemistry
New Editor’s Choice collection ➡ 𝐎𝐫𝐠𝐚𝐧𝐢𝐜 𝐂𝐡𝐞𝐦𝐢𝐬𝐭𝐫𝐲 𝐢𝐧 𝐆𝐫𝐞𝐞𝐧 𝐂𝐡𝐞𝐦𝐢𝐬𝐭𝐫𝐲: 𝐊𝐞𝐲 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭𝐬 🔗 rsc.li/GCOrganic Outstanding research in organic chemistry that showcases advances in green chemistry. 🆓 Free to access until end of July 2026 #GreenChemistry #OrganicChemistry @rsc.org
1mo
Green Chemistry