We study mechanisms promoting genome stability altered in cancer cells
Vincenzo Costanzo
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Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy.
#DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors
www.cell.com/molecular-ce...
Pleased to share our paper. We found surprising widespread glycogen accumulation in A-T due to mitochondrial
impairment that can be improved by targeting the unexpected FNIP2-SERCA2b-axis.
#AtaxiaTelangiectasia #ATM #RareDisease #Metabolism #Mitochondria
www.nature.com/articles/s41...
Another great science appointment is coming up with @labvincenzo.bsky.social and @luijsterburglab.bsky.social! 🧬
🗓️ Join us live on Tuesday, June 9th at 5pm (Rome) / 11am (NYC).
📍 Zoom link: uzh.zoom.us/j/6598481621...
📥 Register here to stay in the loop: docs.google.com/forms/d/e/1F...
www.sciencedirect.com/science/arti...
The Expanding Roles of Homologous Recombination Proteins in Genome Stability
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!
Replicative single-stranded DNA gaps arise when DNA synthesis proceeds past lesions
or difficult-to-replicate regions. This review delineates the pathways that generate,
stabilize, and process these i...
Replicative single-stranded DNA gaps are emerging as central intermediates in the cellular response to replication stress. Replication frequently cont…
Come and join us to celebrate the 10th anniversary of the BCGB, with a great selection of international speakers! Very convenient conference, open to anyone interested in the field of genome biology!
Happy to share new work from my lab by co-authors Peng and Lee-when BRCA1 is absent, RAD51 is busy authors.elsevier.com/sd/article/S...
This work wouldn't have been possible without @angelotaglialatela.bsky.social, Jen-Wei Huang, @giuseppeleuzzi.bsky.social, and members of the labs of @traver.bsky.social, Raphael Guerois, @labvincenzo.bsky.social, Raul Rabadan, @nussenza.bsky.social, @jenscs83.bsky.social, @heyzajr.bsky.social.
