Please RT. Join the sixth edition of our Training Unit @institut_curie
international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...
(1/2) Thrilled to share our findings on the assembly of the Rad51 recombinase filament in Saccharomyces cerevisiae. This work is the result of a wonderful collaboration with Eric Coïc's team at CEA Fontenay-aux-Roses and Angela Taddei's team at the Institut Curie.
www.biorxiv.org/content/10.1...
2) The histone chaperone CAF1 promotes PRIMPOL recruitment to restart stalled forks through ssDNA gap formation. doi.org/10.1093/nar/...
A pleasure to reconnect with the 3R community - Replication, Repair and Recombination - at the 16th 3R Meeting in La Grande-Motte, 18-21 May 2026. Thanks to all for the great science, discussions and atmosphere, and to our sponsors. See you in two years! #3RMeeting #ReplicationRepairRecombination
Rendez-vous à Autrans en juin pour échanger autour d'applications de nos spins préférés ! 👇
Homologous recombination (HR) is essential for the repair of DNA double-strand breaks and the restart of stalled replication forks. A critical step in HR is the formation of Rad51 nucleofilaments, whi...
Abstract. Suppression of single-stranded DNA (ssDNA) gap accumulation at replication forks has emerged as a potential determinant of chemosensitivity in ho
(2/2)Through integrative structural and functional analyses, we identified a large disordered segment of Rad52 that binds Rad51 and functions as an assembly chaperone. It prevents Rad51 oligomerization, facilitates filament formation, and protects filaments from destabilization by the helicase Srs2.