Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...
Beautiful desert views. Beautiful membrane biology.
Join us for the #FASEB Phospholipids in Aging and Disease SRC in Arizona, July 26–30 2026. Registration is now open!
So much better than a Lipid Droplets conference. Also, we're co-located with FASEB Lipid Droplets 😜
A fascinating look at the frankly bonkers, still-mysterious relationship between master membrane regulator PIP2 and its precursor. Another classic from Min Wu's lab!
Another interesting example of how cPLA2 senses nuclear deformation and controls immune cell behaviour. Since the enzyme adsorbs to hydrophobic lipid packing defects, membrane tension and high positive curvature can have similar effects as membrane tension.
www.science.org/doi/10.1126/...
Do you want to know more about how Retromer regulates Rab7 activity in yeast? Of course you do. Check out the new collaboration with Andreas Mayer with work led by Catarina Alves and Kevin Chen.
Sjors Scheres
Big news for correlative cryogenic SMLM/ET! With my colleague Soheil, we (Mahamid and @jonasries.bsky.social labs) indicate lamella-specific illumination can allow 500-1500x higher laser intensities, opening massive new possibilities for correlative imaging #teamtomo
www.biorxiv.org/content/10.6...
I am so excited to co-organize the scientific program for ASBMB 2027 together with Amy Palmer @amypalmerzinc.bsky.social! Please join us in beautiful Boston April 3-6, 2027.
Interested in organizing an ASBMB mini-symposia or workshop? Submit your proposals here!:
www.asbmb.org/annual-meeti...
Our paper on The Lipid Interactome is now published, and the database is open:
lipidinteractome.org
@ohsummi.bsky.social @ohsunews.bsky.social
@nadlerlab.bsky.social @jeremybaskin.bsky.social
Please RT to spread the word.
doi.org/10.1093/bioi...
Excited to share our first collaborative paper of the year- a review on the emerging roles of lipids in flavivirus infection, now published in @cp-trendsmicrobiol.bsky.social. Congrats to Judah (postdoc) for spearheading the work!
@ohsunews.bsky.social
www.sciencedirect.com/science/arti...
Kelly Nguyen
Gerry Hammond
Gerry Hammond
Philipp Niethammer
joe dobbs
Henne lab
Explore breakthroughs in phospholipid research, membrane biology, and aging at this leading scientific conference.
The Retromer coat is conserved in all eukaryotes and is crucial for the correct intracellular sorting of many transmembrane receptors and lysosomal hydrolases. Retromer is an effector of the late endosomal small GTPase RAB7 and is also implicated in its inactivation required for proper endosomal maturation. Here, we explore the role of controlled GTP hydrolysis by the RAB7 ortholog Ypt7 in the formation of Retromer-coated membrane carriers in yeast. Proximity labelling and genetic ablation identify the GTPase Activating Protein (GAP) Gyp6 as a critical regulator of Ypt7 activity in the context or Retromer. Structural studies show that Retromer recruits Gyp6 through its Vps29 subunit, which recognises a specific PL motif and a secondary binding site in the C-terminal domain of Gyp6. This interaction does not occur with other yeast GAPs. Ablation of the Gyp6-Retromer interface or the catalytic activity of Gyp6 leads to the accumulation of tubular structures on endo-lysosomal compartments and to increased association of Ypt7 with Retromer and its cargo Vps10. These results support a model in which Gyp6 controls the switch from Ypt7-dependent Retromer coat assembly and cargo collection to the departure of the carrier through membrane fission and uncoating. ### Competing Interest Statement The authors have declared no competing interest. National Health and Medical Research Council, https://ror.org/011kf5r70, APP2016410 Swiss National Science Foundation, https://ror.org/00yjd3n13, 31003A_179306, 310030_204713, 10.006.083
AbstractSummary. Lipid–protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has lon
Led by Investigator Scientist @hongmiaohu.bsky.social, @kellythd-nguyen.bsky.social’s group in the LMB’s Structural Studies Division have produced the first ever structure of telomerase from yeast.
Read more here: mrclmb.ac.uk/news-events/...
#LMBResearch #cryoEM 🧪
