My latest perspective on #GPCR biased signaling!
GPCR Biased Signaling: Opportunities and Challengeshttps://pubs.acs.org/doi/10.1021/acs.biochem.6c00433
My thoughts on 'curing brain diseases'
open.substack.com/pub/zendudes...
My thoughts on 'curing brain diseases'
open.substack.com/pub/zendudes...
Bryan Roth
Bryan Roth
Bryan Roth
From ai: “Overall sentiment in visible forums appears more supportive among early-career or grant-struggling researchers than among senior PIs with multiple awards, but it is far from unanimous and includes detailed pushback on details rather than outright rejection of the concept.”
From ai: “Overall sentiment in visible forums appears more supportive among early-career or grant-struggling researchers than among senior PIs with multiple awards, but it is far from unanimous and includes detailed pushback on details rather than outright rejection of the concept.”
Interesting title but there is NO EVIDENCE FOR TARGET ENGAGEMENT (e.g. D3/D2 receptor occupancy)!
Title: 'Efficacy and target engagement of dopamine agonist pramipexole for anhedonic depression: a randomized placebo-controlled trial.'
nature.com/articles/s41...
Receptor and cell-type-specific mechanisms in mesocortical dopamine circuits gate chronic pain and comorbid anxiodepression: Neuron www.cell.com/neuron/fullt...
An entire issue of @pubs.acs.org on
#GPCR biased signaling
pubs.acs.org/page/bichaw/...
THIS IS AN IMPORTANT PAPER FOR TRANSLATIONAL-CIRCUIT-BASED THERAPEUTICS
Circuit-specific gene therapy reverses core symptoms in a primate Parkinson’s disease model: Cell www.cell.com/cell/fulltex...
THIS IS AN IMPORTANT PAPER FOR TRANSLATIONAL-CIRCUIT-BASED THERAPEUTICS
Circuit-specific gene therapy reverses core symptoms in a primate Parkinson’s disease model: Cell www.cell.com/cell/fulltex...
Chronic pain and depression are frequently encountered, and traditional analgesics
are insufficient to overcome them. Cai et al. find that neuropathic pain induces a
hypodopaminergic state in the VTA-...
An AAV-based circuit modulation approach that consists of a designer retrograde AAV
capsid, a medium spiny neuron-enriched promoter, and a selected chemogenetic effector
specifically modulates direct ...
An AAV-based circuit modulation approach that consists of a designer retrograde AAV
capsid, a medium spiny neuron-enriched promoter, and a selected chemogenetic effector
specifically modulates direct ...
