James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
Bryan Roth
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My latest perspective on #GPCR biased signaling!
GPCR Biased Signaling: Opportunities and Challengeshttps://pubs.acs.org/doi/10.1021/acs.biochem.6c00433
Receptor and cell-type-specific mechanisms in mesocortical dopamine circuits gate chronic pain and comorbid anxiodepression: Neuron www.cell.com/neuron/fullt...
An entire issue of @pubs.acs.org on
#GPCR biased signaling
pubs.acs.org/page/bichaw/...
Proximity labelling of D1-like dopamine receptors reveals distinct cellular environments and uncovers trafficking proteins that regulate DA mediated behaviors in Drosophila https://www.biorxiv.org/content/10.64898/2026.05.28.728438v1
I'm looking for the HD10.6 cell line--does anyone have it and can they share?
Please RT
NEW CHEMOGENETIC PLATFORM
Genetically engineered rapamycin responsive K2P channels www.biorxiv.org/content/10.6...
Zen thought of the day:
Memory reactivation underlies experience-dependent adaptive regulation of sleep | Science
Another win for chemogenetics www.science.org/doi/10.1126/...
Memory reactivation underlies experience-dependent adaptive regulation of sleep | Science
Another win for chemogenetics www.science.org/doi/10.1126/...
#gpcr Dimers!
Here, we demonstrate stable κOR dimer formation in living cells ... revealing a parallel assembly distinct from previously characterized GPCR dimers that engage only single G protein.
pubmed.ncbi.nlm.nih.gov/42215488/
