Junior Group Leader at @zmbp-tuebingen.bsky.social
NLR and effector biology
Junior Board Member @ISMPMI.bsky.social
🇦🇷🇮🇹🇨🇺
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TIRs are key regulators of plant immunity, but the role of conserved TIR-only proteins has remained unclear.
Here, we compare TIR-only proteins from Arabidopsis and barley and show that they share a conserved role in plant immunity.
www.biorxiv.org/content/10.6...
We've now shed light on the two ways this sophisticated pathogen effector suppresses immunity and learned a lot about NLR biology in the process. Check out the proposed working model:
AVRcap1b connects the TOL pathway to activated NRC helper NLRs to block immune signaling! The highlights are in the original twitter thread. Check it out here:
bsky.app/profile/mpco...
As seen on @biorxivpreprint.bsky.social: our story on how the dreaded late blight pathogen hijacks a helper NLR pathway is now out in its final form! 🎉
Meet AVRcap1b: the two-faced effector 🧵👇
www.science.org/doi/10.1126/...
Huge thanks to my co-lead @jmadhuprakash.bsky.social, and to @kamounlab.bsky.social for all the support! 🙏 Also big shoutout to the structural phylogenomics wizard @amiralito.bsky.social for his amazing contributions to the story!
Two faces calls for two papers! Check out our companion paper showing how the same AVRcap1b stalls stepwise assembly of the tomato NRC3 resistosome mid-build!
Check out the paper and the original thread:
bsky.app/profile/jmad...
www.science.org/doi/10.1126/...
