Two faces calls for two papers! Check out our companion paper showing how the same AVRcap1b stalls stepwise assembly of the tomato NRC3 resistosome mid-build!
Check out the paper and the original thread:
bsky.app/profile/jmad...
www.science.org/doi/10.1126/...
As seen on @biorxivpreprint.bsky.social: our story on how the dreaded late blight pathogen hijacks a helper NLR pathway is now out in its final form! š
Meet AVRcap1b: the two-faced effector š§µš
www.science.org/doi/10.1126/...
A plant pathogen effector suppresses an activated helper NLR via a host ENTH domainācontaining protein, NbTOL9a.
šØ New @biorxivpreprint alert! šØ
We are thrilled to share our latest findingsābuilding on our earlier work on suppressors of helper NLRs of the NRC familyāa Phytophthora infestans L-shaped effector captures resistosome assembly intermediates of tomato NRC3!
www.biorxiv.org/content/10.1...
1/10
AVRcap1b connects the TOL pathway to activated NRC helper NLRs to block immune signaling! The highlights are in the original twitter thread. Check it out here:
bsky.app/profile/mpco...
Video
Jogi Madhuprakash
Mauricio Contreras
Host killing by necrotrophs is really complex.
Using a 29-gene knockout series in Botrytis cinerea, we show that removing nearly all known cell death-inducing proteins and major phytotoxins is not sufficient to prevent host necrosis.
Check out the paper: www.biorxiv.org/content/10.6...
Three weeks left to apply for a chance to present at our new ECR webinar series: Rising Stars of IS-MPMI!
We especially encourage applications from researchers based in the Global South! See the quoted thread for info on how to self-nominate.
Sponsored by @getgenome.bsky.social
Congrats to all involved! @hsuanpai.bsky.social, Madia, @adamrbentham.bsky.social, Ben, Enoch, @delaconcepcionjc.bsky.social, Dave, @cemstevenson.bsky.social, Angel, @lderevnina.bsky.social , @tolgaboz.bsky.social ,
@mjbanfield.bsky.social
Huge thanks to my co-lead @jmadhuprakash.bsky.social, and to @kamounlab.bsky.social for all the support! š Also big shoutout to the structural phylogenomics wizard @amiralito.bsky.social for his amazing contributions to the story!
We've now shed light on the two ways this sophisticated pathogen effector suppresses immunity and learned a lot about NLR biology in the process. Check out the proposed working model:
now published!!! @johninnescentre.bsky.social @leahmcphillips.bsky.social
academic.oup.com/nar/article/...
International Society for Molecular Plant-Microbe Interactions
Botrytis cinerea is a necrotrophic plant pathogen with an extremely wide host range. During invasion, the fungus induces rapid host cell death and proliferates in the necrotic tissue. The mechanisms o...
