The ESCRT machinery mediates repair of damaged lysosomal membranes. But how does it recognise damage? Authors @nature report LASER, a fast-forming protein assembly that detects Ca2+-leakage from sites of lysosomal injury and recruits ESCRTs there.
shorturl.at/T9zM6
Today, Nobel laureate (and former NIGMS Advisory Council member) gave an NIH-wide lecture. She enthusiastically signed the #BethesdaDeclaration.
She was introduced by NIH Director Bhattacharya...(likely slightly awkward)
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Online today in @nature.com - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s41...
full text available here 👉 rdcu.be/em0VG and thread 👇
📝 Now online - the Review "Molecular and structural mechanisms of nutrient sensing in the mTORC1 pathway" from @robzonculab.bsky.social and co.
#mTORC1 #PrimaryNutrientSensor #AminoAcidSensor #CholesterolSensor #Metabolites
Read it here: authors.elsevier.com/a/1mrsu_M0e4...
Fantastic work by Aakriti Jain @aakritijain.bsky.social in team
with Claire Goul and the Laboratory for Genome Research reveals the LASER pathway and its core component TFG as critical
for rapid ESCRT-dependent lysosomal membrane repair, pointing to a deep connection with neurodegeneration!
Structural and cell biology NPG publication two-fer today: lysosome signaling structural biology tinyurl.com/mt3uc96k with @robzonculab.bsky.social and mitophagy initiation tinyurl.com/3rpjyfjt with @martenslab.bsky.social @lazaroulab.bsky.social and @hummerlab.bsky.social
A powerful piece by M. Gessen
I can't do it justice by excerpt
go read it (gift link)
www.nytimes.com/2026/01/24/o...
Travelling home from the 2026 Autophagy GRC organized by Rushika Perrera and Oliver Florey, inspired to strive for an equally scientifically excellent and comprehensive 2028 Autophagy GRC in Italy together with Roberto Zoncu. Mark your calendars for March 12-17 2028!
@robzonculab.bsky.social
Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social
Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸
The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.
So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...
www.nature.com
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
