Comparative genomics generates results fast - but preserving the context needed to understand them over time is much harder.
I’ve written a perspective on GLUE as a long-lived, data-oriented knowledge base: projects as persistent scientific objects rather than disposable pipelines.
sl1nk.com/Y0O4H
Genomics has a data rot problem.
Pipelines change. Alignments are regenerated. Assumptions disappear. Context is lost.
This post explains why GLUE was built around data immutability and durable scientific objects.
gluetools.substack.com/p/data-immut...
Recovery of viral RNA from centuries old human tissue is genuinely exciting.
This changes the horizons for recovery of ancient virus genomes.
Robert J. Gifford
Studying immune gene evolution is rarely about a lack of data, it’s about keeping data, biology, and interpretation aligned as everything changes.
New GLUE Genomics post: from viral genomes to immune genes, using interferon lambda as a case study.
gluetools.substack.com/p/glue-resou...
Most bioinformatics tools put software first and data second. GLUE does the opposite.
In this blog post (link in reply), I provide a plain-language explanation of its data-oriented philosophy, and why that matters for reproducible virology.
gluetools.substack.com/p/data-orien...
Studying immune gene evolution is rarely about a lack of data, it’s about keeping data, biology, and interpretation aligned as everything changes.
New GLUE Genomics post: from viral genomes to immune genes, using interferon lambda as a case study.
gluetools.substack.com/p/glue-resou...
As virus discovery accelerates, integrating new sequences meaningfully is becoming a central challenge.
Flavivirus-GLUE provides an open framework for multi-scale comparative genomic analyses of flaviviruses.
gluetools.substack.com/p/flavivirus...
MLCA genotyping in GLUE is currently available for a range of viruses, including:
HCV, HBV, HEV, dengue, chikungunya, West Nile virus, yellow fever virus, rabies virus, and lentiviruses (SRLVs, EIAV).
Comparative Genomics Across the Host–Pathogen Interface
gluetools.substack.com
Comparative Genomics Across the Host–Pathogen Interface
