I carry out research into the evolution of viruses and their impact on host species. Open science.
Robert J. Gifford
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Most bioinformatics tools put software first and data second. GLUE does the opposite.
In this blog post (link in reply), I provide a plain-language explanation of its data-oriented philosophy, and why that matters for reproducible virology.
gluetools.substack.com/p/data-orien...
Genomics has a data rot problem.
Pipelines change. Alignments are regenerated. Assumptions disappear. Context is lost.
This post explains why GLUE was built around data immutability and durable scientific objects.
gluetools.substack.com/p/data-immut...
Comparative genomics generates results fast - but preserving the context needed to understand them over time is much harder.
Iāve written a perspective on GLUE as a long-lived, data-oriented knowledge base: projects as persistent scientific objects rather than disposable pipelines.
sl1nk.com/Y0O4H
Studying immune gene evolution is rarely about a lack of data, itās about keeping data, biology, and interpretation aligned as everything changes.
New GLUE Genomics post: from viral genomes to immune genes, using interferon lambda as a case study.
gluetools.substack.com/p/glue-resou...
Recovery of viral RNA from centuries old human tissue is genuinely exciting.
This changes the horizons for recovery of ancient virus genomes.
Studying immune gene evolution is rarely about a lack of data, itās about keeping data, biology, and interpretation aligned as everything changes.
New GLUE Genomics post: from viral genomes to immune genes, using interferon lambda as a case study.
gluetools.substack.com/p/glue-resou...
MLCA genotyping in GLUE is currently available for a range of viruses, including:
HCV, HBV, HEV, dengue, chikungunya, West Nile virus, yellow fever virus, rabies virus, and lentiviruses (SRLVs, EIAV).
Iāve just published a new Substack post explaining how MLCA genotyping works in GLUE, and how to run it yourself locally using Docker.
It covers the evolutionary logic behind MLCA and the practical workflow for using it.
gluetools.substack.com/p/how-mlca-g...
Great read! Congratulations @katarinazimmer.bsky.social on your insightful @knowablemag.bsky.social piece exploring the remarkable biology of the Aedes aegypti #mosquito knowablemagazine.org/content/arti...
As virus discovery accelerates, integrating new sequences meaningfully is becoming a central challenge.
Flavivirus-GLUE provides an open framework for multi-scale comparative genomic analyses of flaviviruses.
gluetools.substack.com/p/flavivirus...
