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New paper out in J Med Chem showing that covalent targeting of C775 has the potential to treat osimertinib resistant lung cancer. Really proud of this work and the team that did it! @nudrugdiscovery.bsky.social @nucancer.bsky.social @crhorizons.bsky.social pubs.acs.org/doi/10.1021/...
5mo
Inhibitors of epidermal growth factor receptor (EGFR) kinase activity are clinically effective treatments for lung cancers driven by activating mutations in EGFR. Resistance to inhibitors develops ove...
pubs.acs.org
Covalent Alkynylpyridopyrimidinones Targeting Cysteine 775 of the Epidermal Growth Factor Receptor Overcome Resistance to Current Therapies
Mike Waring
It's official, our med chem Senior Research Associate @hannahstewart92.bsky.social is the world's fastest scientist @guinnessworldrecords.com guinnessworldrecords.com/world-record...
May 13, 2025
Prof. Mike Waring (@mikewaring.bsky.social), Chair of Medicinal Chemistry, Newcastle University #facesofscience #chemsky #sciencesky
CRUK Newcastle Drug Discovery Group
Nikol Zografou Barredo, PhD Student (Medicinal Chemistry), Newcastle University #facesofscience #chemsky #sciencesky
Apr 7, 2025
Apr 2, 2025
Something makes me think that this invite might have been autogenerated...
Group trip to the pub / watch the bins being emptied.
Starting the @mosmedcdt.bsky.social conference. It will get better from here!
This work also provides some hopefully useful information on how to generate and interpret SAR of covalent inhibitors.
Apr 11, 2025