How did animal senses evolve? Max Coyle et al. used choanoflagellates to uncover TRPW, ancient ion channels predating animal somatosensory receptors. TRPW links microbial prey ecology to evolution of receptor structure, sensory organelles, & multicellular processing.
www.biorxiv.org/content/10.6...
Love these little guys - seen while walking in the park
wow
Announcing BoltzMol-1, BoltzProt-1, and the Boltz API
boltz.bio/boltzmol-bol...
Posted this in LinkedIn. Shameless advert for some new structures 👉 lnkd.in/gT9Be3tH. But more structural biologists here! Nice to have Claude control my ChimeraX. At least for visualizations and analysis I can see it really speeding up things. IF you know what you’re doing and what to ask for.
Very sad to learn that Steve White has passed away.
Excited to be presenting this work today at the 3DEM Gordon Research Seminar and later this week at the Gordon Research Conference. Looking forward to the discussions and feedback!
www.grc.org/three-dimens...
Video
The results here re 3D classification are quite impressive. Would be interesting to see how much the LPP improves classification of near-native samples with extreme compositional heterogeneity (e.g. derived from cellular fractions)
I learned so much from watching past editions of @ccpem.bsky.social Spring Symposium, so I agreed to my talk being recorded even though this is stepping well out of my comfort zone (public speaking isn't my strongest skill). Anyway, here is the recording: www.youtube.com/watch?v=AKTf...
#CCPEM
The 2026 Gordon Research Conference on Three Dimensional Electron Microscopy will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
Phase plates can in principle overcome the poor image contrast in electron cryo–microscopy (cryo-EM) and the resulting limits on the structural reconstruction of small proteins. However, previous desi...
In a series of 3 papers and preprints, we’re thrilled to share with you the working laser phase plate. In collaboration with research led by Holger Müller at UC Berkeley, this is a huge innovation in imaging to make small and faint objects inside cells visible. bit.ly/4vK9LVn
Two next-generation open models for small-molecule and protein prediction, now self-serve through the Boltz API.
In a series of 3 papers and preprints, we’re thrilled to share with you the working laser phase plate. In collaboration with research led by Holger Müller at UC Berkeley, this is a huge innovation in imaging to make small and faint objects inside cells visible. bit.ly/4vK9LVn
Continuous recording beam image shift speeds up single particle and tomographic data collection.
www.nature.com/articles/s41...
Guillaume Gaullier
New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀
Biohub
Biohub
The authors report continuous recording beam-image shift (CR-BIS), a continuous recording strategy that overcomes camera delays to markedly accelerate cryo-EM data acquisition, improving throughput fo...
The Candidate Phyla Radiation (CPR) represents a bacterial superphylum estimated to include between 15–50% of all bacterial species, yet CPR bacteria remain challenging to culture and have been primar...
