My first manuscript in MPI colours! With @tothpetroczylab.bsky.social, we show that AlphaFold PAE-derived contact probabilities are well calibrated to the fraction of true interface contacts across experimentally determined protein dimers.
www.biorxiv.org/content/10.6...
New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀
new pili for the lilliputians (CPR/Patescibacteria) 👇
#MicroSky
I am very grateful to @lorneproteins.bsky.social for the opportunity to speak and share my work! Such a great atmosphere, thank you for the warm welcome and excellent questions.
Wonderful spirochete asymmetric flagellar structural work by @lucatroman.bsky.social Grateful to be part of the story supported by @debnathghosal.bsky.social
📣 New paper alert! This is a story of molecular tricks that let spirochetes (spiral-shaped bacteria) drill through tissue. www.biorxiv.org/content/10.6...
www.biorxiv.org
The Candidate Phyla Radiation (CPR) represents a bacterial superphylum estimated to include between 15–50% of all bacterial species, yet CPR bacteria remain challenging to culture and have been primar...
New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀
📣 New paper alert! This is a story of molecular tricks that let spirochetes (spiral-shaped bacteria) drill through tissue. www.biorxiv.org/content/10.6...
S3: Luca Troman-Spirochete flagellar motors rotate in opposite directions; periplasmic flagella are more complex.
Treponema denticola. 2 motors, thick and thin flagella. SPA Native flagella isolation w optiprep cushion, inner core, outer sheath, mystery density - modelangelo! 🕵♀️
#lorneproteins2026
Video
It has been great to be part of this team, thank you to everyone involved!
The Candidate Phyla Radiation (CPR) represents a bacterial superphylum estimated to include between 15–50% of all bacterial species, yet CPR bacteria remain challenging to culture and have been primar...
🌀 We solved the structure for T. denticola periplasmic flagella!
I'm very happy to finally showcase this work. A huge collaborative effort between myself, @bindusmitapaul.bsky.social, @debnathghosal.bsky.social, Jack Kim, @banfieldlab.bsky.social, Eric Reynolds and the Chris Fenno lab.
🦠 Enjoy!
Excited to be presenting this work today at the 3DEM Gordon Research Seminar and later this week at the Gordon Research Conference. Looking forward to the discussions and feedback!
www.grc.org/three-dimens...
Debnath Ghosal
Debnath Ghosal
Lorne Proteins
Luca Troman
Luca Troman
Luca Troman
The 2026 Gordon Research Conference on Three Dimensional Electron Microscopy will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀
The Candidate Phyla Radiation (CPR) represents a bacterial superphylum estimated to include between 15–50% of all bacterial species, yet CPR bacteria remain challenging to culture and have been primar...www.biorxiv.org
Join #EMBOCryoEM to get a comprehensive foundation in advanced single-particle and cellular tomography techniques – we'll cover the entire workflow from sample preparation to data collection and image processing.
https://s.embl.org/cry26-01-bl
Apply by: 11 May 2026
@embo.org
Structural basis for curvature generation and functional specialization in spirochete flagella https://www.biorxiv.org/content/10.64898/2026.02.04.703737v1
Debnath Ghosal
Wonderful collaboration with #EricReynolds, #JillBanfield, and #ChrisFenno labs. Terrific effort from @lucatroman.bsky.social who drove the high-resolution work, great support from @bindusmitapaul.bsky.social and #JackKim, @CCeMMP, @UniMelbMDHS, @CGCPT.
