Our mission is to understand fundamental processes in vascular biology through creative thinking and scientific excellence.
navedolab.faculty.ucdavis.edu; @ucdavis.bsky.social
Manuel F. Navedo
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👋The fourth episode of our podcast series just dropped. navedolab.faculty.ucdavis.edu/podcasts/
This one identifies a tissue-specific signaling mechanism that distinguishes how heart and vascular muscles control calcium intake.
Check out the paper here: ahajournals.org/doi/10.1161/...
This work is relevant because it shows that CaV1.2 channels can be regulated by the same signal (e.g. PKA) but the mechanism of that regulation is different - Same signal, different logic. And you may ask, so what???
CaV1.2 channels are major #antihypertensive drugs💊 Problem? They hit heart and vessels alike, like a sledgehammer when a scalpel is needed. Now that we know vessels use S1928 while the heart uses Rad, we can finally think about building that scalpel🎯
