Our mission is to understand fundamental processes in vascular biology through creative thinking and scientific excellence.
navedolab.faculty.ucdavis.edu; @ucdavis.bsky.social
Manuel F. Navedo
👋The fourth episode of our podcast series just dropped. navedolab.faculty.ucdavis.edu/podcasts/
This one identifies a tissue-specific signaling mechanism that distinguishes how heart and vascular muscles control calcium intake.
Check out the paper here: ahajournals.org/doi/10.1161/...
This work is relevant because it shows that CaV1.2 channels can be regulated by the same signal (e.g. PKA) but the mechanism of that regulation is different - Same signal, different logic. And you may ask, so what???
CaV1.2 channels are major #antihypertensive drugs💊 Problem? They hit heart and vessels alike, like a sledgehammer when a scalpel is needed. Now that we know vessels use S1928 while the heart uses Rad, we can finally think about building that scalpel🎯
Someone got really great news from @ahascience.bsky.social on his Career Development Award. Congrats Miguel!!!
#proudmentors
@ucdavis.bsky.social, @ucdavishealth.bsky.social
🩸 Plot twist! Nosebleeds in hereditary hemorrhagic telangiectasia aren't just leaky pipes - VSM that surround and control them are secretly breaking down too!
New in @CircRes 🔥 Great collab @ucdavishealth.bsky.social with Rong Wang @ucsfhealth.bsky.social
www.ahajournals.org/doi/10.1161/...
The team went to the #biophysical and #modeling side to understand how the CaBP1 protein regulates L-type channels. Great collab with Jim Ames, Hell Lab & #MnMLab
@ucdavis.bsky.social
pubs.acs.org/doi/10.1021/...
Check out our reviews on "Translating cardiovascular ion channel and Ca signalling mechanisms into therapeutic insights". Massive effort from junior investigators, emerging researchers & other leaders in the cardiovascular field. @ucdavis.bsky.social
doi.org/10.1113/JP29...
Just in time for the Holidays, our latest paper on how #amyloidbeta regulates the spatiotemporal properties of vascular L-type channels - implications for vascular function.
Great work by Jade and team! @ucdavis.bsky.social, @ucdavishealth.bsky.social
physoc.onlinelibrary.wiley.com/doi/10.1113/...
🚨Not all channels are created equal🚨 New work from our lab shows that PKA regulates vascular CaV1.2 via S1928 — NOT Rad — phosphorylation, overturning the assumption that cardiac and vascular channels are regulated the same way.
www.ahajournals.org/doi/10.1161/...
Happy Monday everyone!!!
Happy to share this book chapter by my awesome partner
Made Nieves-Cintron and #MnMLab members on
"Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome"
Highly relevant topic these days!!!
link.springer.com/chapter/10.1...
