I suggest someone write an article about service contract costs called "The Revolution Eats Its Children".
📄 Loop-mediated regulation and base flipping drive RNA cleavage by human mitochondrial PNPase
✍🏼 @bmhallberg.bsky.social @hdas29.bsky.social
📔Nucleic Acid Research @narjournal.bsky.social
Surface ice ruining your cryo-ET lamellae? We showed you can sublimate it away — inside the SEM, no extra hardware, no devitrification. 🧊→✨
New preprint from @KarolinskaInst 3D-EM 🧵👇
Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export?
Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
#TeamTomo if you want to use CTF-corrected 3D subtomos from AreTomo3 in RELION v.5.1 you can use this updated script:
github.com/Phaips/aretomo3torelion5
KI researchers have captured the first detailed molecular snapshots of human polynucleotide phosphorylase in action, revealing how this essential mitochondrial enzyme degrades RNA through an elegant base-flipping mechanism. Published in @narjournal.bsky.social 🧪 #mitochondria doi.org/10.1093/nar/...
We challenged the assumption that sublimation devitrifies cryo-ET samples. It doesn't — if you control the temperature.
Cleaner lamellae. Less curtaining. Same vitrification. No new hardware. www.biorxiv.org/content/10.6...
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Video
The next #CryoEM Current Practices Webinar speaker will be Mark Herzik from UCSD speaking on "Old tools, new tricks: engineering better cryoEM sample preparation workflows through design and chemistry" 6/25/2026 at 12 PM ET / 9AM PT
Register here :
us02web.zoom.us/webinar/regi...
Contribute to Phaips/aretomo3torelion5 development by creating an account on GitHub.
Abstract. Human polynucleotide phosphorylase (hPNPase), a trimeric exoribonuclease, is crucial for maintaining mitochondrial RNA metabolism, including the
📄 Loop-mediated regulation and base flipping drive RNA cleavage by human mitochondrial PNPase
✍🏼 @bmhallberg.bsky.social @hdas29.bsky.social
📔Nucleic Acid Research @narjournal.bsky.social
Reese Richardson
Karolinska Institutet
Video
Edward T Eng
Cryo-EM: the revolution continues doi.org/10.1107/S205...
