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KI researchers have captured the first detailed molecular snapshots of human polynucleotide phosphorylase in action, revealing how this essential mitochondrial enzyme degrades RNA through an elegant base-flipping mechanism. Published in @narjournal.bsky.social 🧪 #mitochondria doi.org/10.1093/nar/...
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Abstract. Human polynucleotide phosphorylase (hPNPase), a trimeric exoribonuclease, is crucial for maintaining mitochondrial RNA metabolism, including the
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Loop-mediated regulation and base flipping drive RNA cleavage by human mitochondrial PNPase
Karolinska Institutet
📄 Loop-mediated regulation and base flipping drive RNA cleavage by human mitochondrial PNPase ✍🏼 @bmhallberg.bsky.social @hdas29.bsky.social 📔Nucleic Acid Research @narjournal.bsky.social
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