Had a wonderful time at the @bsgct.bsky.social annual conference!
I was delighted to be able to share our work on human airway epithelial cell culture for transplantation and how this contributes to the @epicentr.bsky.social efforts towards a cell and gene therapy for airway epidermolysis bullosa.
Yuki Ishii, @jess0rr.bsky.social Sam Janes, @robhynds.bsky.social @epicentr.bsky.social & team identify Wnt pathway activators as potential pro-regenerative therapies in their compound screen in human airway basal cells.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social!
We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.
doi.org/10.1242/jcs....
Grateful to receive the Fairbairn Award for this presentation and for the opportunity to learn and discuss new ideas and progress in the gene and cell therapy fields.
@charitydebra.bsky.social @cureeb.bsky.social @goshcharity.bsky.social @royalsociety.org @uclchildhealth.bsky.social
Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.