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🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social! We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo. doi.org/10.1242/jcs....
Apr 14, 2025
doi.org
Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.
Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies
Epithelial Cell Biology in ENT Research Group UCL