Hello all- we have a new paper on bioarchives, a massive study of lymph node HIV reservoirs at the single cell level. We show that T follicular helper cells are not the major HIV reservoirs during ART. This should prompt reevaluation of curative strategies www.biorxiv.org/content/10.6...
Our latest research preprint demonstrating chemokine- based targeting of mRNA-LNPs to cytotoxic CD8 T cells and NK cells. A first in class gene therapy strategy. www.biorxiv.org/content/10.1...
Happy to announce publication of our first therapeutic mRNA-LNP paper!
In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs | Science Immunology www.science.org/doi/10.1126/...
Michael Betts
Fractalkine-conjugated mRNA-LNPs effectively target cytotoxic effector CD8 T cells for transient in vivo reprogramming.
We tested whether CD8+ T cells trapped in lymph nodes of SIV infected rhesus macaques during antiretroviral therapy interruption were able to prevent reactivation of viral replication and prevent rebo...
Selective in vivo reprogramming of cytotoxic effector CD8+ T (Teff) cells holds tremendous promise as a therapeutic tool but has not yet been accomplished. Here, we demonstrate that fractalkine-conjug...
The multifaceted and long-lived nature of HIV-1 reservoirs has proven to be a formidable obstacle in the development of a therapeutic cure of HIV-1. One of the major dimensions of the HIV-1 reservoir ...
