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Hello all- we have a new paper on bioarchives, a massive study of lymph node HIV reservoirs at the single cell level. We show that T follicular helper cells are not the major HIV reservoirs during ART. This should prompt reevaluation of curative strategies www.biorxiv.org/content/10.6...
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The multifaceted and long-lived nature of HIV-1 reservoirs has proven to be a formidable obstacle in the development of a therapeutic cure of HIV-1. One of the major dimensions of the HIV-1 reservoir ...
www.biorxiv.org
Selective infection and loss of PRDM1+ LN Tfh cells in uncontrolled HIV infection precludes formation of Tfh reservoirs under ART
Michael Betts