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🕊️ Structural Acceleration Does a bigger genome mean faster structural evolution? No. We found lineage-specific bursts of structural innovation in Birds (Aves) and Ants (Hymenoptera) that are distinct from genomic expansion. (4/5)
Huge congrats to lead authors Qiuzhen Li & Diandra Daumiller! Thanks to @martinsteinegger.bsky.social for all the great tools! 📄 Preprint: biorxiv.org/content/10.6... 🖥️ Try the Tool: she-app.serve.scilifelab.se
⚙️ A Bipartite Evolutionary Mode The eukaryotic proteome isn't a uniform soup. We resolve it into two distinct modes: A rigid "Architectural Core" (Cytoskeleton/Chaperones) A highly plastic "Operational Engine" (Metabolism/Translation) (3/5)
Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure. We computed 300 trillion alignments across 1,542 species to map the tree of life. 🧵👇 (1/5)
The future of drug design is in AI. RareFoldGPCR: Agonist Design Beyond Natural Amino Acids. Paper: www.biorxiv.org/content/10.1... Code: github.com/patrickbryan...