I still like small data but I'm not opposed to big data. We study #metabolism, #genetics, #pediatric inborn errors & cancer. Views are my own.
DeBerardinis Lab at UT Southwestern Medical Center
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Advancing our understanding of how metabolism shapes neuronal development: doi.org/10.1172/JCI1...
@rjdlab.bsky.social & team generated neural progenitor cells from patients, finding that L2HG epigenetically activates MYC to impair neuronal differentiation—and the effect is reversible
Incredible chance to learn about genetics, from the fundamentals to the latest science. I attended this course when I was a PhD student in the 90s and have lectured in it for the last dozen or so.
And science aside, there's nowhere better to be in late July than Bar Harbor, ME. See you there.
12 panels total. No supplemental data. There are dot blots and a northern blot. It says "data not shown" at one point.
That was a different era.
#RareDiseaseDay2026: “think of zebras (rare diseases) when you hear hoofbeats.” On Feb 28, we wear stripes to recognize patients with rare diseases and support rare disease research in CRI and the McDermott Center at UT Southwestern. Thanks to the Rare Disease CoE for all you do for these patients.
New paper from Dr. Wen Gu on the impact of L-2-hydroxyglutarate deficiency on neural stem cell function and neuronal differentiation. Interesting connection between an IEM and chronic oncogene activation. Thanks to Dr. Bushra Afroze and her patients for participating.
www.jci.org/articles/vie...
We already thought @haozhulab.bsky.social hung the (liver-shaped) moon🌙 & now his #relentlessdiscovery is promulgated. Check out Chp 6, "When Our Bodies Autocorrect," p140 to read how somatic mutations could give us "hope." Great topic, @roxannekhamsi.bsky.social! 🧪 Watch out #booktok 🤓
This kind of stable, sustained support can transform a career: @hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits. Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA
I am so grateful for this honor - grateful to my mentors, lab, and family. Thank you @seanjmorrison.bsky.social for your support. And how great to be elected with some very good friends and two awesome UTSW colleagues, Elizabeth Chen and Joel Elmquist. Feeling very fortunate today.
DeBerardinis Lab at UT Southwestern Medical Center
DeBerardinis Lab at UT Southwestern Medical Center
Journal of Clinical Investigation
DeBerardinis Lab at UT Southwestern Medical Center
DeBerardinis Lab at UT Southwestern Medical Center
Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...
My first co-authored paper appeared 30 years ago today.
pubmed.ncbi.nlm.nih.gov/8626737/
The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...
DeBerardinis Lab at UT Southwestern Medical Center
DeBerardinis Lab at UT Southwestern Medical Center
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
