Interested in DNA damage and the mechanisms of mutagenesis?
We are hiring post-doctoral scientists as part of the amazing CAUSE Cancer Grand Challenge team. Biochemistry, genomics and computational biology... tinyurl.com/yc5xs3wa
tinyurl.com/4unu5uu9
CAUSE www.cancergrandchallenges.org/cause
Please join us in NH (perfect place to be in August!) for this inspiring conference organized by @petrovadmitri.bsky.social and Joy Bergelson. Very interdisciplinary, so I look forward to learning tons of new concepts.
www.grc.org/function-of-...
A gene is recurrently mutated in cancer. But do these mutations really cause the disease? Or are they merely selected during normal tissue evolution?
Postdoc D. Cheek had the creative idea to use patient ages to try and answer this question.
Read new paper out here:
www.nature.com/articles/s41...
Exciting breakthrough technology from the lab, now live in
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
GRC presents Function of Evolving Systems, a conference on .
www.grc.org
Mutations may be enriched in tumor samples because they promote carcinogenesis or because they promote clonal expansions in healthy tissue. This study mathematically disentangles these two possibiliti...
Excited to share our ‘Evolutionary characterization of lung cancer metastasis’ in #TRACERx & #PEACE, published today in @nature.com in collaboration with @charlesswanton.bsky.social @nickymcgranahan.bsky.social @zaccasimo.bsky.social at @ucl.ac.uk & @crick.ac.uk. www.nature.com/articles/s41...
The conference is quickly filling up! Don't wait to sign up. We also received some funding and can offer fellowships to graduate students and postdocs. Won't cover the whole cost but will certainly make it much easier!
Kamila Naxerova
Kamila Naxerova
Martin Taylor
Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr
Tumor promotion through the lens of evolution
This review grew out of many long conversations, shared ideas, and lively discussions
It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk
rdcu.be/fdC2J
Did you catch our news during #MarkSymposium?
We’re accepting applications for our 2026 Emerging Leader Awards, now offering $1 million over 4 years & open to investigators worldwide!
Submit your LOI by April 30: themarkfoundation.org/emerging-lea...
#ResearchFunding
DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...
📢 Postdoc position available in my lab
We study mutagenesis, population genetics, and Mendelian genomics—linking the origins of mutations to their biological and disease consequences.
Details about research directions:
labs.utsouthwestern.edu/seplyarskiy-...
Please reach out if interested.
Nature - Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...
Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social
