Happy to have the chance to share this commentary by @will-milligan.bsky.social & me:
rdcu.be/fldBs.
I'm excited to share that our work studying gene dosage response curves (GDRCs) is now out in Cell Genomics (@cellpress.bsky.social).
www.cell.com/cell-genomic...
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BREAKING:
New proposed OMB regulation, applying to all federal grants, requiring grant reviews by senior political appointees and re-emphasizes that "peer review remains advisory and does not replace agency discretion".
#standupforscience
public-inspection.federalregister.gov/2026-10817.pdf
Milind et al. explore why loss-of-function variants and duplications tend to have
average effects in the same direction on 94 complex traits. Using gene dosage response
curves (GDRCs), they gather evi...
www.cell.com
Nature Reviews Genetics - In this Comment, the authors argue that understanding the genetic basis of adaptation requires considering the genetic architecture and ecological properties of traits...
Congratulations Jeff! It's been really wonderful to have you in the lab! I cannot wait to see all the fantastic work that will come out of your future lab.
...and trainees, Jeff is an amazing scientist and mentor! If you ever have a chance to work with him you should seize it with both hands!
For an update on our preprint about the mysterious signature SBS5, see: www.biorxiv.org/content/10.1.... New analyses throughout, but see Figure 5 in particular.
Nikhil Milind
Stand Up for Science!
“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and @gcbias.bsky.social: www.biorxiv.org/content/10.1...
The program for the 2026 New York Population Genetics meeting, hosted by at the @simonsfoundation.org on March 9th 2026, is now up: events.simonsfoundation.org/event/7c91dd....
My lab read this paper www.biorxiv.org/content/10.1... for journal club, and had some thoughts on the strong claims made about the number of signals of selection found.
More than two-thirds of the papers we've published since the lab started in 2019 have international co-authors, who have greatly enriched the science that we do
bsky.app/profile/jros...
Molly Przeworski
www.biorxiv.org
A major focus of human genetics is to map severe disease mutations. Increasingly that goal is understood as requiring huge numbers of people to be sequenced from every broadly-defined genetic ancestry...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
Delighted to share our latest preprint: Julie Zhu identifies a surprising reason why the genetic architecture of brain-related traits is so different than other traits. Check it out!
Molly Przeworski
Graham Coop
Molly Schumer
I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July.
We'll work at the intersection of statistical genetics, population genetics, and machine learning.
Jonathan Pritchard
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
