#PEQG26 folks! I will be presenting my postdoc project with @jkpritch.bsky.social and @jeffspence.github.io about inferring population structure dynamics over time with tensor decomposition on ARG. The talk will be at the James Crow Talk session on Wednesday. Look forward to seeing everyone there!
🚀 We are introducing PerturbPair (with Taka Kudo) — a platform that combines parallel Perturb-seq and optical pooled screening (PerturbView) in primary cells to systematically map at massive scale how genetic perturbations reshape cellular states across modalities.
www.biorxiv.org/content/10.6...
@nature.com on Egli's human embryos base editing. www.nature.com/articles/d41... Quotes me on worries about risky efforts. Egli says that would be premature; yes, that's my point. I also agree w/Fyodor Urnov's that preimplantation testing is (almost always) a better solution even if this proves safe
We built a joint experimental and computational platform for scalable multi-modal single-cell chemical screens — profiling RNA, protein (including phospho-signaling), and chromatin accessibility responses to thousands of small molecule perturbations in parallel. www.biorxiv.org/content/10.6...
The ‘base editing’ technique that researchers used is far from ready for the clinic, but critics worry that it will spur a rush to commercialize the approach.
Combined Optical Pooled Screens and Perturb-seq!
Great new work by Romain Lopez & Taka Kudo. This is one of a series of papers from our lab (here, with Aviv Regev) using perturbations to interpret human genetics; a key revelation for me is how transferable the mouse perturbs are to human genetics.
Excited to be at #PEQG26! I have a poster tonight on measuring selection on intraspecies variation in large microbial communities (415W), would love to hear what folks think!
Pareto curves in track racing:
So, this weekend I was playing around in Claude Code with a database of track times (all Diamond Leagues and global champs from last 12 years).
I really like this viz of tactics in the men's 5000m, one of the most tactical events in track.
Our new paper is out! Tweetorial coming soon!
Our new paper doi.org/10.1098/rspb... on long-term genetic threats to small populations finds that "mutational meltdown" (bad mutations fixing) is less of a problem than "mutational drought" (too few good new mutations) @wmawass.bsky.social @uliseshmc.bsky.social @jeremyjberg.bsky.social 1/5
Abstract. Habitat loss contributes to extinction risk in multiple ways. Genetically, small populations can face an ‘extinction vortex’—a positive feedback
doi.org
🚀 We are introducing PerturbPair (with Taka Kudo) — a platform that combines parallel Perturb-seq and optical pooled screening (PerturbView) in primary cells to systematically map at massive scale how genetic perturbations reshape cellular states across modalities.
www.biorxiv.org/content/10.6...
Jonathan Pritchard
Jonathan Pritchard
Sophie Jean Walton
Yuval Simons
Romain Lopez
Joanna Masel
Accounting for recurrent mutation in the frequency spectrum of rare alleles https://www.biorxiv.org/content/10.64898/2026.05.29.728884v1
