Awesome paper and super useful resource of CRISPR-based screens to identify regulators of #LipidDroplet biology under different metabolic conditions: crisprlipid.org
Preprint 🧵!
I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition!
BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a
www.biorxiv.org/content/10.6... (1/6)
Final week to apply: GSO Leadership Academy 10
The GSO Leadership Academy is an interactive program designed to support researchers who want to develop leadership skills for academia and beyond.
📅 Application deadline: March 1, 2026
🔗 More information: gsonet.org/foerderprogr...
Interested in caveole and/or lipid metabolism? We have two master thesis projects available in the lab @unipotsdam.bsky.social starting September or October. For more details 👇
www.matthaeus-lab.de/post/04-2026...
It was fun writing this with David @dgershlick.bsky.social! Check it our if you want to hear our view on small #GTPases networks in endosomal trafficking :) part of the themed issue on Membrane trafficking edited by @fromme-lab.bsky.social and Philippe Chavrier
www.sciencedirect.com/science/arti...
1/9
🚨 New paper out in Nature Metabolism! Chapter 2 of our mitochondria zonation story (following our 2024 Nature Communications work). We asked how zonated liver mitochondria adapt when lipid flux surges. 🧵👇
www.nature.com/articles/s42...
🚨🚨Last day to register for the next annual meeting of Club Exocytose-Endocytose !!!🚨🚨
Invited speakers: M. Stroeber, G. D'Angelo and @christlet.bsky.social
📍 Centre Paul-Langevin, Aussois, France
📅 May 27–29, 2026
Get ready for exciting science!!
Registration here exoendo.org/evenement/28...
We have two exciting master thesis projects available in the lab. Please see the announcements below. Start date is flexible, but earliest September or October 2026. If you are interested, please send...
www.matthaeus-lab.de
Read the latest chapters of Methods in Enzymology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
Endosomal GTPases, while often used as markers for specific endosomal organelles, functionalize the surface of endosomal compartments into biochemical…
Using single-cell tissue imaging and spatial proteomics to study mitochondria–lipid droplet coupling in hepatocytes, PLIN5 phosphorylation is identified as a mediator of lipid flux and nutrient stress...
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that:
www.nature.com/articles/s41...
New perspective on caveolae www.nature.com/articles/s41...
Helena Watson
Sarah Cohen
Claudia Matthaeus
Jeremy Baskin
@PoratShliomLab
Fran Bottanelli
Club Exo Endo
This Perspective discusses the mechanisms underlying both the formation and scission of caveolae, with a focus on highlighting the role of specific lipids in regulating and coupling these processes.
Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...
CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...
