We investigate the patterns and mechanisms of structural variation in disease. Mobile DNA. Led by Professor Jose M.C. Tubio
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Jose Tubio’s lab - Mobile Genomes
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Today in
@science.org:
We are pleased to present our last work entitled:
"Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis"
by Zumalave et al.
www.science.org/doi/10.1126/...
LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...
Agora ás 21 h na #radiogalega visitaremos o laboratorio de @mobilegenomes.bsky.social do @cimususc.bsky.social para falar de meigas, minións, xenes saltaricos e ... Hamlet.
Vale, e tamén do seu último paper en @science.org
🔬Ciencia gallega en @science.org!
El investigador Jose Tubío del grupo @mobilegenomes.bsky.social, nos cuenta los detalles de su trabajo en esta entrevista completa en @farodevigo.es 📰⤵️
www.farodevigo.es/galicia/2026...
Huge congrats to Sonia Zumalave @bernardo-rodriguez.bsky.social @mobilegenomes.bsky.social es.bsky.social Jose Tubio & team!
Happy to have (modestly) contributed!
@inserm.fr @insermpacacorse.bsky.social
@cnrsbiologie.bsky.social @univcotedazur.bsky.social @ircan.bsky.social
Key findings:
1️⃣ L1s drive large-scale rearrangements including translocations (not just insertions)
2️⃣ Frequency of these events was largely underestimated by short-reads
3️⃣ They occur EARLY, thus potentially acting as drivers
#Genomics #CancerResearch #MobileDNA @nanoporetech.com
